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With the US Vogue editor's presiding, invitations to the New York soiree are more sought after than vintage Hermes bags, and the movie and catwalk gliteratti vy to take fashion honours.
On Monday, Anna will share hosting duties with British starlet Carey Mulligan and Italian designer Miuccia Prada.
The gala will celebrate Impossible Conversations – the museum's spring blockbuster exhibition exploring the striking parallels between Miuccia and her fellow countrywoman, the late Elsa Schiaparelli, a contemporary of Coco Chanel.
Meanwhile, Jennifer Lopez and funky newcomer Azealia Banks are rumoured to be performing.
As we eagerly anticipate the biggest event in the Big Apple's social calendar, here’s a look back at some of the best moments from past years.
Check back on Monday night for live updates from our Twitter account - @hellomagbeauty