Greek mythology holds that Agamemnon stopped there on his way back from Troy to Mycenae, seduced by 'the sweet music of this fertile isle'.
In modern times Spetses, which is a three-hour boat ride from Athens, was to become a retreat for heroes, tycoons and socialites, seducing among them, Jackie Kennedy Onassis.
Next week, the magical island will attract the world's attention in earnest again when 40-year-old Prince Nikolaos of Greece and his fiancée Tatiana Blatnik become man and wife.
Though not a royal wedding in the strictest sense - his father King Constantine was deposed in 1974 – the nuptials are likely to be a magnificent affair, graced by many members of Europe's reigning houses.
Among the guests of honour are newlyweds Crown Princess Victoria of Sweden and husband Prince Daniel, who tied the knot in lavish style earlier this summer.
Also attending are her siblings, Carl Philip and Madeleine. Spain's royal family will be heavily represented as the country's Queen Sofia is Constantine's sister.
The groom's mother Anne Marie, meanwhile, is the sister of Queen Margrethe of Denmark.
Tatiana, an ice cool blonde with ravishing cheek bones, who works for Diane von Furstenberg, is also from a distinguished family.
Educated in Switzerland and the US, the 29–year-old is the granddaughter of Ellinka Countess von Einsiedel.
The couple will tie the knot at sunset in the whitewashed 19th-century monastery of Ayios Nikolaos.
Guests are then invited to toast their happiness during a reception overlooking the ancient harbour where the crystal waters of the Mediterranean lap Garifalo beach.