Speaking at a press conference for his patronage Walking With The Wounded, the Prince – who recently returned from a four-month tour of duty in Afghanistan – confirmed his participation.
"They've given their all for the cause of freedom," said Harry, before joking to his American and Australian comrades, "I'll have a brew ready for you when you reach us at the South Pole".
This latest challenge will be the second adventure for Harry, who teamed up with disabled servicemen to trek to the North Pole in April 2011. This trip will be a month long and finish just before Christmas, 2013.
Walking With The Wounded's co-founder Ed Parker set up the charity after his nephew was seriously injured in Helmand province, where Harry undertook his most recent deployment.
He explains the Prince's emotional history with the organisation. "When Harry flew back from Afghanistan, he was on an aircraft with several wounded soldiers," Ed says.
"That had a real, lasting impact on him. He spent 12 hours with these men on the plane and realised how much their lives have changed, and I think that's part of his motivation in supporting the charity's work."