The reality TV star seemed to send out a message to the world as she posed in front of illuminated Spanish script reading "todo es possible" (everything is possible) at a Hollywood party.
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The 29-year-old was at Katy Perry's home for the singer's Labor Day party with friends including her BFF Malika Haqq (far right), who viewers of Keeping up with the Kardashians will recognise from the series.
It was Khloé's first public appearance since news broke of her husband Lamar Odom's alleged arrest on Friday morning. And though it wasn't visible in the Instagram snap she posted, her wedding ring was sparkling on her finger at the bash.
According to reports the NBA player was detained for "driving under the influence of alcohol and/or drugs".
The troubled basketball star was pulled over on the motorway in his white Mercedes 4x4 for going too slowly and was taken to a nearby police station by the California Highway Patrol and held on $15,000 bail.
Police say that the NBA player had been driving in a "serpentine manner", TMZ reports.
Lamar initially ignored the authorities and drove past three exits before coming to a stop, at which point he "showed obvious signs of intoxication".
His loyal wife is said to be determined to help her husband of four years get his life back on track as he struggles to overcome substance abuse issues.