An amusing video that has emerged online shows the star footballer, 29, attempting to sing one of Ed's classics, Lego House.
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As Wayne sits alongside the Brit-award winning crooner and warbles along out of pitch, Ed strums on his guitar and is heard stifling a giggle as he encourages the athlete on.
'Thanks for a great night mate!' Wayne Rooney wrote to Ed Sheeran on Instagram
Regardless of Wayne's failed attempt, the Manchester United captain seems to have had a whale of a time hanging out with his 23-year-old singing idol.
The striker had just attended Ed's sell-out tour in the northern city when he rocked up to the pub for the small after-party.
"Brilliant time at Ed Sheeran concert last night. Thanks for a great night mate!" the footballer captioned a photo of the pair on Twitter and Instagram.
Wayne's wife Coleen also took to the micro-blogging site to congratulate the hitmaker on his musical success. "Congratulations on your Number 1@edsheeran ..... Fantastic!!" she posted after hearing that his track Thinking Out Loud had topped the UK Official Singles Chart.
Ed Sheeran and Wayne Rooney performed at a Manchester pub after a concert
Last month, Ed's latest album X was reported as the best-selling album of 2014 so far.
Speaking at the same time, Ed revealed the inspiration behind his Thinking Out Loud music video, which sees the red-haired singer taking over a ballroom dancefloor.
"My original concept was to have a couple walk in and do some made ballroom dancing," he said. "At first I was going to get two talented dancers but as was the idea was formed, I thought hmm maybe I should have a crack at this. If rugby players can do it on Strictly Come Dancing then maybe I can too."
West Yorkshire-born Ed added: "Dancing can be the most fun thing in the world but in the lead-up to finishing this video, I was so frustrated. I have never wanted to quit something so much. At some points, I felt like saying to the choreographers 'You do this, I'm going to stand in the background.'"