The couple have left no doubt that she will be adding to her brood soon, which already consists of two-year-old son Rafael and one-year-old daughter Rivka.
A report from The Sun newspaper suggests Jacqui will welcome the new arrival with her 45-year-old partner in June, putting her at approximately six months pregnant.
The British stars are seemingly wasting no time in expanding their family, but have been reticent about announcing their baby joys to the world.
It only emerged last week that what they had decided to name their little girl, who was delivered at Portland Hospital in London by Caesarean section only 14 months after Rafael came into the world.
The proud parents met at a friends party in 2009, but didn't start dating until a year later. Nine months into their romance Jacqui discovered she was pregnant with Rafael, who was born in September 2011.
Their plans to wed were revealed in the weeks before Rivka was delivered and the family now live in a £6million mansion.
Guy was married to singer Madonna for eight years and they have biological son Rocco, 13, together plus adopted son David, eight. Guy’s latest film The Man From U.N.C.L.E is currently in post-production and is due out in 2015. He also wrote the screenplay for the movie starring Henry Cavill, Hugh Grant and Armie Hammer.
“In the early 1960s, CIA agent Napoleon Solo and KGB operative Illya Kuryakin participate in a joint mission against a mysterious criminal organisation, which is working to proliferate nuclear weapons” the IMDb synopsis reads.
Jacqui is best known for her work with Elle Macpherson, Virgin Atlantic and starring in the opening credits for James Bond film Die Another Day.
Guy and Jacqui's publicists declined to comment at this time.