The video has already received more than one million views and has all the ingredients necessary to become a success, telling the story of heartbreak between two characters played by Enrique and America actress Camilla.
Camilla was known for her three-year relationship with Spanish tennis player Fernando Verdasco, who is now dating Enrique's sister Ana Boyer as revealed in HELLO!'s sister magazine HOLA! last October.
The release of Enrique's new video, which was recorded in Santa Barbara, California and directed by Colin Tilley, comes amid growing rumors that his 12-year relationship with Anna Kournikova is on the rocks.
Neither Enrique or Anna, who met when she starred in the video for his 2002 hit Escape, has commented on the situation.
Camilla is every inch the screen siren in the video, conquering the camera with her striking looks and dressed in a black dress with a plunging neckline.
The Brazilian-born American actress, who has worked on films such as 10,000 BC and Push, already has experience in the music business having starred in the video for Lovebug by the Jonas Brothers.
The video for Heart Attack tells the story of a relationship that ends with a painful breakup which leads Enrique to consider his life from the edge of a bridge.
"It's something that has happened to us all," he said. "And is a story that everyone can relate to."
- Who is Camilla Belle?
Born in California to an American father and Brazilian mother, Camilla Belle Routh speaks English, Portuguese and Spanish and can play the piano.
At nine months she began to gain publicity and later landed roles in series and TV movies. Her first major film was the sequel to Jurassic Park and she has since appeared in films like The Patriot, When a Stranger Calls, 10,000 BC and Push.
The role that cemented her fame however was when she starred opposite George Clooney in a TV advertisement where she opted for a cup of coffee instead of the actor. Father of Invention (2010), From Prada to Nada (2011), Breakaway (2011) and Open Road ( 2012), among others, are also some of Camilla's silver screen roles.
Camilla, who is 1m 71 tall, loves to watch soap operas with her grandmother Deborah, who she often sees when visiting her family in São Paulo. In fact Camilla's name was given to her by her mother to honor a star of a Brazilian soap opera.
But Camilla is both beautiful on the outside and on the inside and is involved in various charities as well as being an international ambassador for the organization "Kids With A Cause", a charity which provides assistance to needy children.
Camilla has previously dated singer Joe Jonas, and was rumoured to be in a relationship with Robert Pattinson months before splitting from Fernando Verdasco in 2010.