The Material Girl singer posted a series of candid shots on Instagram from inside the luxurious bash, which was held in a villa in Cannes on Saturday.
Madonna poses with Kate Moss at her lavish birthday bash
One showed her clad in a black beaded flapper-style dress, her elegant blonde curls pulled back with a sparkling headband, as she knelt down alongside Kate, 40, who looked stunning in a little black number with sparkling straps, fishnet tights and a hat.
Other guests at the glamorous party included Bono, David Blaine and fashion designers DSquared2 – Dean and Dan Caten.
Madonna's children Rocco, Lourdes, Mercy and David were also there to help their mum celebrate in style.
Posting a picture of her son David looking dapper in a suit, polka dot bow tie and top hat, Madonna wrote, "My escort for the evening! #swag #boom #livingforlove".
Another photo appeared to show her adopted daughter Mercy posing alongside a giant "M" adorned with lights.
Madonna's children were also there to help her celebrate
Madonna also shared a snap of Dean and Dan Caten posing with another guest in front of the elaborate display, which she captioned, "Grazie infinite for the enchanting evening!!!".
Madonna posted a flashback photo from the 80s
Meanwhile, to mark her special day, Madonna posted a throwback picture from the 1980s for her fans.
Channelling Marilyn Monroe in the black-and-white snap, the queen of pop captioned the photo, "In my birthday suit."