The 19-year-old, who was in Australia recently to DJ at the Good Life festivals, told Aussie magazine Woman's Day, "I love my mum".
"I don't care what people say," said Connor, who the couple adopted back in 1995. "I know that me and mum are solid. I love her a lot. My family means everything.
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"Yeah, I love my music, but the family comes before everything else."
Connor and his sister Isabella, who the then couple adopted two years before him, have been known to have a strained relationship with Nicole because of their ties to the controversial Church of Scientology, of which their dad Tom is also a longtime follower.
When Tom and Nicole split in 2001 after 11 years of marriage, their children chose to live with their father. And six years later it came to light that they no longer called Nicole "Mum".
"My kids don't call me mommy, they don't even call me mom. They call me Nicole, which I hate and tell them off for it," she said in 2007.
Nicole with her son Connor in 2004
Three years later the Oscar-winning actress spoke out about her children's choice to live with their dad.
"They live with Tom, which was their choice," she said. "I'd love them to live with us, but what can you do?"
Nicole, 46, was last pictured in public with her son six years ago at the Annual Kids' Choice Awards in Los Angeles. He was then just 13.
Nicole now spends most of her time in Nashville, Tennessee, with her second husband Keith Urban and two children Sunday Rose and Faith Margaret.
Tom has another daughter, seven-year-old Suri, with ex-wife Katie Holmes.