Annie Lennox, Rita Ora and Emma Thompson are among the famous faces to front the high street giant's new campaign.
Supermodel Alek Wed, campaigner Baroness Lawrence of Clarendon OBE, fashion designer Lulu Kennedy, chef Rachel Khoo and structural engineer Roma Agrawal make up the rest of the cast.
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M&S unveiled the new leading ladies in a group photograph shot by renowned fashion photographer Annie Leibovitz.
Previous stars to have fronted the campaign include Ellie Goulding, Grace Coddington, Karen Elson and Helen Mirren.
The campaign launches nationwide on 31 March, featuring the new Spring/Summer collection.
"Our Spring/Summer campaign is a celebration of style and accomplishment," says Patrick Bousquet-Chavanne, the Executive Director of Marketing.
"These dynamic leading ladies represent the unique and diverse women of a modern Britain. They are united in their extraordinary achievements but confident in their differences.
"Marks & Spencer is a democratic brand which is relevant to women of all ages and strands of life; it is therefore natural for M&S to celebrate women in this way.
"M&S is extremely proud to have convened such an extraordinary group of exceptional women; this campaign is the embodiment of true British style, quality, diversity and success."
The ads were shot on several different idyllic locations around Britain, including Camber Sands and the Cotswolds.