"I just want to take a minute to say we just wanted to send our love and condolences to all the people who lost loved ones in the tragedy in Connecticut," said the 69-year-old early on in the concert, dedicating their song Wild Horses to applause from the audience.
The high energy gig brought to a close a run of special anniversary concerts – titled The Stones 50 and Counting tour – staged by the iconic rockers in London and the US. And it seemed the group, which also features newly-engaged Ronnie Wood and Keith Richards, had saved the best for last as they were joined by several star guest performers.
Lady Gaga almost stole the show as she took to the stage in New Jersey to duet with Mick on Gimmie Shelter. The Born This Way singer put on a high energy performance, matching Mick shimmy for shimmy, stomping around the stage on impossibly high platform shoes and wearing a revealing monochrome striped catsuit.
After her turn with the band she told her Twitter followers: "I had a life dream to be transported in a time machine to 1973 NJ, beer + badboys. Someone heal me it happened + then I sang with the Stones.
Gaga broke the news earlier this month she would be joining Mick and co, tweeting: "I am so honoured and excited to announce I will be performing with @rollingstones on Dec15 for their 50th Anniversary Concert One More Shot. He had me at, 'Hello, it's Mick.'"
Also taking part in the concert was Bruce Springsteen, who collaborated on Tumbling Dice. Mick joked the Boss had "walked to the show". The Black Keys also appeared, joining the music legends in a performance of Who Do You Love. And Katy Perry's beau John Mayer brought along his guitar to feature on Going Down.
Mick wrapped up the show by hinting there might be more concerts in store for the band. "This is our last show... of the 50th anniversary tour. Hope to see you again soon," he said.