The 62-year-old French designer has revealed that he will be focusing on his haute couture collections instead, as well as devoting his time to the brand's fragrances and accessories.
Jean Paul Gaultier has announced the end of his ready-to-wear lines
"For some time, I have found true fulfilment in working on the haute couture," the designer told WWD in a letter. "It allows me to express my creativity and my taste for research and experimentation."
"At the same time, the world of ready-to-wear has evolved considerably," he added. "Commercial constraints, as well as the frenetic pace of collections don't leave any freedom, nor the necessary time to find fresh ideas and to innovate."
Jean Paul, who has created iconic designs such as Madonna's cone shaped bra during her Blonde Ambition tour, will still be unveiling his last ready-to-wear women's collection at Paris Fashion Week in September.
"This is a new beginning," he said. "I will be able to express again my creativity fully and without constraints."
The French designer will continue to create costumes for musicians including Kylie Minogue who will soon be embarking on a new tour, as well as Eurovision winner Conchita Wurst.