Amy Schumer turns 45: see her incredible then and now transformation

Amy first burst onto the scene as one of comedy's brightest new voices, quickly becoming known for her sharp wit, self-deprecating humour and refreshing honesty.

As her fame grew through projects including Trainwreck, I Feel Pretty and Life & Beth, she also became a relatable figure for women navigating body image pressures in Hollywood.

Unlike many stars, Amy refused to pretend she had all the answers. That honesty became even more apparent following the birth of her son Gene in 2019. After welcoming her little boy via C-section and battling severe endometriosis symptoms, the actress found herself facing a number of health challenges.

In 2021, Amy underwent surgery to remove both her uterus and appendix due to complications related to endometriosis.

Months later, she revealed she had also undergone liposuction. Sharing a swimsuit photo on Instagram in 2022, Amy admitted she had never expected to have cosmetic surgery but felt it was the right choice after years of physical struggles.

"I feel good. Finally," she wrote at the time. Later, speaking on Chelsea Handler's podcast Dear Chelsea, Amy explained why she felt compelled to be transparent.

"I just wanted to say that, because if anybody sees me in pictures or anything and they're like, she looks thinner, and whatever: it's because I had a surgery," she said. "It's too hard, and I just want to be real about it."

The actress revealed she weighed 170 pounds after her procedures and was focused on regaining her strength.

Following surgery, Amy turned to weight loss medication Wegovy. The results were dramatic and she lost around 30 pounds quickly, but the side effects proved overwhelming.

Appearing on Watch What Happens Live with Andy Cohen, Amy revealed she felt so unwell she could barely function.

"I was one of those people that felt so sick and couldn't play with my son," she said.

Although she acknowledged that the medication worked, she said the physical toll wasn't worth it.

"I lost 30 pounds so quick. I looked great, but I couldn't lift my head off the pillow. So what's the point?"

The actress later explained that she carries a genetic variation linked to severe nausea, which likely contributed to her difficult experience.

In early 2024, Amy found herself making headlines for a different reason.

Fans had begun commenting on changes to her appearance, particularly what they described as a noticeably fuller face.

Rather than ignore the speculation, Amy sought medical advice and received an unexpected diagnosis: Cushing syndrome.

The condition occurs when the body produces excessive levels of cortisol and can lead to weight gain, swelling and a rounded facial appearance.

At the time, Amy revealed she had been undergoing extensive testing and feared there could be something seriously wrong.

Thankfully, doctors determined her condition would resolve without major intervention.

Finding answers brought enormous relief. "Thank God for that," she said, explaining that the diagnosis ultimately helped her better understand what was happening to her body.

Three years after her difficult experience with Wegovy, Amy decided to try a different medication.

In 2025, she revealed she had begun taking Mounjaro and was having a much more positive experience.

"I was like puking, I couldn't handle it," she said of her earlier treatment. "So, yeah, that's been great. Mounjaro's been great."

The actress has continued sharing updates with fans while remaining committed to transparency around her health choices.

Weight loss has only been one part of Amy's health story, she has also become increasingly vocal about endometriosis, hormonal changes and perimenopause.

In 2025, she revealed she had begun taking estrogen and progesterone and noticed dramatic improvements.

"My symptoms of being in perimenopause have disappeared," she shared.

"My hair is fuller, my skin is better, I have more energy."

The improvements extended beyond the physical. Amy said she felt more like herself again and wanted other women to understand that they didn't have to simply suffer through symptoms in silence.

Throughout every stage of her transformation, Amy has consistently returned to one message: honesty matters.

She has repeatedly encouraged women to advocate for themselves medically, seek answers when something feels wrong and reject unrealistic expectations around appearance.

"The shaming and criticism of our ever-changing bodies is something I have dealt with and witnessed for a long time," she said in 2024.

"I want so much for women to love themselves and be relentless when fighting for their own health in a system that usually doesn't believe them."

As Amy celebrates her milestone birthday, she appears happier and more comfortable in her own skin than ever.

In late 2025, she surprised followers by deleting her older Instagram posts, later joking that she had done so "for no reason".