Meet Michelle Pfeiffer's two lookalike sisters — including the actress who once dated George Clooney

The Pfeiffer sisters were born to parents Richard "Dick" and Donna Pfeiffer and grew up in a suburb of Orange County, California. The trio were true California girls. They attended Fountain Valley High School. It's rumored that Michelle often skipped school to spend the day on the beach instead.

Dedee, who was born Dorothy Diane, started acting when she was 21, seven years after Michelle won the Miss Orange County beauty pageant. She made her TV debut in 1985 on the crime drama Simon & Simon. 

That same year, Dedee starred alongside Michelle and Jeff Goldblum in the thriller film Into the Night. She went on to appear in several other films, like Vamp, The Allnighter, and The Horror Show, and she acted alongside Michelle again in 1996's Up Close & Personal.

During the early '80s, Dedee briefly dated George, long before he became a Hollywood household name. The two met in 1982 and even starred in the 1989 action film, Red Surf, together.

George recalled his fling with Dedee to Variety during a 2021 conversation with Michelle while the two reflected on their '90s rom-com One Fine Day. Michelle shared that she hadn't seen George since the film's premiere, to which George responded: "I think that was a plan of yours, actually. That's called the restraining order. I met you in 1982 when I was dating your sister, Dedee. You were living in Santa Monica, and she was living above the garage."

While George and Dedee's connection didn't last, she went on to have several other relationships. In 1996, the actress married TV producer Gregory Fein. They divorced in 2001. That same year, Dedee tied the knot with director Santiago Gomez, with whom she shares two sons.

The actress and Santiago divorced in 2006. Three years later, Dedee married Irish actor Kevin Ryan. But, the two split in 2012.

Michelle and Dedee are more embedded in Hollywood than their younger sister Lori. But, she did spend a few years acting. Lori is credited with three appearances – 1990's The Adventures of Ford Fairlane, 1999's The Sky Is Falling, and the 2014 short film Less. She also worked behind the camera, receiving a production assistant credit on Into the Night.

Outside of her career, Lori tied the knot with her husband, musician and songwriter Jude Cole in 1993. They went on to have two sons, Jesse and Ethan, who also stay out of the spotlight.