Dressed all in black, 44-year-old Charlene appeared to be in great spirits, a clear indication that she is slowly adjusting back to royal duties following her health setback.
WATCH: Princess Charlene and Prince Albert share touching video ahead of 10th wedding anniversary
She wore a chic black dress custom-made by Terrence Bray, which featured a fit-and-flare structure and a boat neckline. The royal finished off her look with a black lace veil and what appeared to be rosary beads.
Princess Charlene recently returned home to Monaco after battling an ear, nose and throat infection which saw her spend much of 2021 in her home country of South Africa.
Back in May, the mum-of-two opened up about the ill health that has plagued her. "My state of health is still fragile, and I don't want to go too fast," the royal told Monaco Matin. "The road has been long, difficult and so painful. Today I feel calmer."
Princess Charlene seen at the Vatican on Tuesday
Commenting on her return to the public eye, which included appearances at Monaco Fashion Week and the Grand Prix, the royal said: "When I returned to the Principality, I focused all my energy on my children, my husband and my health because they are my priority."
Prince Albert has previously confirmed that Princess Charlene was dealing with "exhaustion, both emotional and physical", after collapsing on 1 September due to complications following one of several surgeries for a severe and ongoing ear, nose and throat (ENT) infection.
The royals after a private audience with Pope Francis
She was rushed to Netcare Alberlito Hospital, and the Palace released the following statement to People: "On the night of September 1, Her Serene Highness Princess Charlene of Monaco was taken to hospital after becoming ill due to complications from a serious ENT infection. Her Highness is being closely followed by her medical team, who say her condition is reassuring."
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