The two have a big week ahead of them, as Monday, 14 November marked the official start of their return to NBC's studio 6A, during which they will host their show live to a studio audience of 200 people for a week.
The beginning of the show was emotional from the get-go, with Jenna asking Hoda: "Should we do this?" before walking out to a standing ovation from their fans.
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The two were quick to get weepy-eyed, walking out hand in hand to greet and hug their fans. "We're having a moment right here. It is so good to see you, we've missed you," Hoda said, as the two smiled ear to ear.
Her co-star added: "You know, Hoda and I feel –and I can speak for both of us – like we are coming home to 200 of our closest friends. Thank y'all so much."
Promising a very big day, the two detailed what is to come for the episode, including an appearance from former First Lady Michelle Obama, who is promoting her new book, The Light We Carry, as well as plenty of surprises and giveaways.
Fans appeared more than ready to see the two live in an Instgram Story shared on 4th Hour with Hoda & Jenna's official account
The big comeback to a live studio audience prompted the two hosts to reflect on moments of change and new chapters, and the two gave insight into recent changes in their family life.
"We had kind of a monumental moment at my house," Hoda announced, revealing that: "Haley's very last day of wearing a pull-up diaper was last night," and that she told her: "Instead of looking at it like an ending, I said, 'But guess what, starting tomorrow you have a whole new chapter.'"
Hoda and Jenna have been teasing plenty of surprises to come
As the two spoke about saying goodbye to certain things and phases, Jenna reflected on her own family's recent change, having moved from their TriBeCa apartment to a house away from the city. Though she admitted it was hard for her and her children, she maintained they were both resilient and happy.
Speaking of her daughter Mila, nine, the mother-of-three held back tears as she revealed that the tween wrote for a school assignment that her new school made her feel "free" and that there was a place for her there.
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