Announcing the news on Twitter, Piers said: "I'm quitting Life Stories after 12 years and 100 shows. My final one will be with my fabulous friend @kategarraway and she will then present the remaining 3 planned shows of the next series as I leave ITV to host my new global daily show. It's been a blast!"
WATCH: Kate Garraway breaks down in tears after NTAs win
The father-of-four, who had told fans he would be sharing "big news" at 10pm on Thursday, left fans in shock with the announcement but many shared their joy at Kate joining.
"Yes, terribly sad to see @piersmorgan go. But @kategarraway is going to do a fantastic job on the last 3," said one.
Piers and Kate have been good friends for years
A second follower added: "Do love life stories & am gutted you are going, although I quite like Kate & looking forward to seeing her doing life stories."
"Huge amounts of luck to both @piersmorgan and @kategarraway #LifeStories," wrote a third.
Kate is yet to speak out about the news but it would have no doubt been well received after a few tough weeks.
The mother-of-two revealed to fans over the weekend that she was suffering from an inflamed cornea.
Kate Garraway will appear on Piers Morgan's last ever Life Stories episode
"Ouch! But thanks to the brilliant @nhs team @moorfieldsuae not permanent. Inflamed cornea caused probably by wearing my contacts for too long on some very long days recently. Hence the glasses on @gmb on Friday," she revealed alongside a picture of her swollen eye.
"And to think I nearly didn't get it checked out as was wanting to get back home to do some physio with Derek. A further reminder if you are a carer, parent or anyone really you have to sometimes put yourself first otherwise you are no use to anyone you are trying to help. 48 hours of putting drops in every hour day AND night & I will be back on track. Hope everyone is having a lovely Sunday."