The former Eastenders star, 50, was due to perform a Charleston to 'Step in Time' from Disney's Mary Poppins with his professional dance partner after sailing through to the quarter-finals of the beloved BBC dance competition.
A spokesperson for the BBC said: "Unfortunately Nigel has sustained an injury which means he is unable to perform and has had to withdraw from Strictly".
The actor is understood to have suffered a leg injury which prevented him from continuing in the competition, and forced him to pull out of the quarter final just four hours before the live show was due to air.
Other reports claim Nigel did not attend morning rehearsals, with the remaining celebrity dancers informed of his absence this afternoon.
Nigel's shock exit comes after the star kicked off the season at the top of the leaderboard with his powerful Paso Doble to Nirvana's 'Smells Like Teen Spirit'.
His departure from the show will no doubt come as a disappointment to Strictly fans, who hailed Katya's acclaimed choreography as the 'best' in the show.
Taking to X (formerly Twitter) after the dancing duo dazzled in the ballroom with their impressive Salsa, one person wrote: "The choreography of Katya is simply world-class and second to none. And Nigel executes perfectly. Such a brilliant pairing!" while another added: "One of the best of the night. It deserved 9. They were super synchronised. And Katya is one of the best choreographers on the show."
It is not clear whether an elimination will still go ahead this week.Typically, the Strictly Come Dancing final requires at least four partners to compete - but after Amanda Abbington also withdrew from the competition, Nigel's exit could mean that all four remaining couples are safe this week.
The remaining celebrities are Ellie Leach, Annabel Croft, Layton Williams and Bobby Brazier.