The message, which was shared on Thursday night, read: "Prince Harry and Meghan, The Duke and Duchess of Sussex and all of us at Archewell stand with the people of Ukraine against this breach of international and humanitarian law and encourage the global community and its leaders to do the same."
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It's the couple's first update on their website this year, the last one being in November, and it comes days after Boris Johnson addressed the nation to also condemn the Russian president.
No other members of the royal family have spoken out about the crisis.
The message was shared on their Archewell website
Harry and Meghan's statement was issued on the same day that it was announced that the couple will be honoured at the NAACP Image Awards for heeding the call to social justice.
The pair were named as recipients of the prestigious President’s Award, which recognizes special achievement and distinguished public service, and has previously been awarded to Muhammad Ali, Jesse Jackson, Colin Powell, LeBron James, Rihanna, Jay-Z and Lauryn Hill.
In a joint statement, they shared that it was a "true honor" and they added that the efforts by the US civil rights organization on racial justice were as "vital today as they were nearly 115 years ago".
The couple are currently living in California
"We’re proud to support the NAACP’s work and to also partner with the organization on the newly created annual NAACP-Archewell Digital Civil Rights Award, which will be bestowed to Dr Safiya Noble as part of the 53rd NAACP Image Awards," they added.
Derrick Johnson, president of the NAACP, said: "We're thrilled to present this award to Prince Harry and Meghan, the Duke and Duchess of Sussex, who together have heeded the call to social justice and have joined the struggle for equity both in the US and around."
The NAACP-Archewell Digital Civil Rights Award recognizes leaders creating "transformational change at the intersection of social justice and technology".