While it's been less than a week since Harper left, the reality of it is now sinking in, and Ali, 58, shared a new photo on Instagram that provided a glimpse inside their slightly emptier home life.
A photo she posted on Instagram saw the pair all dressed up, presumably for some kind of event or party, with Ali in a patterned blue and white sundress and George, 62, in a preppy suit with a fun striped tie.
The actress and comedienne commented on their empty nester status by captioning her photo with: "To help deal with the pain of being empty nesters – I made George dress like it was his first day of class at a boy's elementary school…"
Several of the commenters responded with laughter emojis and witty remarks like: "He understood the assignment and gets bonus points for smiling," and: "You forgot to have him hold a sign with questions, like, what does he want to be when he grows up?" as well as: "Nailed it. And it gets easier."
Harper starts at Vanderbilt University in Nashville, Tennessee this Fall alongside Katharine Haffenreffer, Good Morning America colleague Lara Spencer's youngest. Harper's older sister, Elliott, will start her junior year at Brown University.
After dropping her off at college, Ali shared a snap of herself and George walking away hand in hand, and emotionally wrote alongside it: "We dropped our baby off at college. Everyone is saying 'she's ready to launch'! But… I don't think I'm ready!
"I don't want to stop making pasta with vodka sauce, picking up wet towels, cuddling up to her familiar scent. As Joni Mitchell once wrote – 'the bed's too big, the frying pan too wide'."
She continued: "I know our daughter will thrive. But man, it's brutal on the parents. If you feel inclined – please send me baked goods. I'll be under my covers."
Lara was feeling just as sentimental as she commented on Ali's photo: "I hear you sister. I am at the airport with a giant lump in my throat. I don't want to leave. It's going to feel too real. The house will be too quiet. The music won't be blaring. Her room will be neat. My clothes will not be missing. I don't like it one bit.
Of the prospect of becoming empty nesters, he added: "Ali and I met and got married within nine months, and had a baby nine months later, so we've never known a house without kids really." The parents' advice for their youngest was to "go with the flow. Be engaged. Be curious."
Get the lowdown on the biggest, hottest celebrity news, features and profiles coming out of the U.S. Sign up to our HELLO! Hollywood newsletter and get them delivered straight to your inbox.